Arrested pneumatisation of the skull base
Arrested pneumatisation of the skull base is an anatomical variant that most commonly occurs in association with the sphenoid sinus. It is known that the sphenoid bones undergo early fatty marrow conversion antecedent to normal pneumatisation. However, for unclear reasons, some individuals experience failure of pneumatisation before respiratory mucosa has fully extended into sites of early fatty marrow conversion. These individuals are then left with persistent atypical fatty marrow adjacent to the sinus that persists into adulthood. If unrecognised, imaging features may at times create diagnostic difficulty in interpretation of skull base CT and MR scans.
Since it is a developmental abnormality, it usually manifests as an incidental finding. No specific clinical symptoms are attributed to this entity.
The proper process of pneumatisation of the skull base and paranasal sinuses start at the age of 4 months and develops through to young adulthood. Red bone marrow is being replaced by fatty marrow prior to pneumatisation of the paranasal sinuses, including the sphenoid bone. The precise mechanisms that remain largely unclear. This bone marrow conversion precedes the invasion of epithelial cells to form the respiratory mucosa. When one of the steps described above is halted, no or reduced pneumatisation of the sinus will occur.
It usually occurs in regions of normal or accessory sphenoid sinus pneumatisation including the basisphenoid bone, pterygoid processes and clivus. Contiguous involvement across multiple sphenoid subsites is common.
Imaging consists of CT and MR studies involving the skull base. The non-expansile nature of the lesion is best evaluated at the inferior orbital fissure and Vidian canal, which are not displaced nor disrupted.
Characteristic features on CT are the presence of:
- a non-expansile lesion with
- internal curvilinear calcifications and
- sclerotic margins
Hallmark of MR imaging is:
- the presence of internal fat and microcystic components
- the absence of any mass effect
- hyperintense fatty component
- hypointense microcystic and calcified components
- sclerotic border is hypointense
- no enhancement of the lesion after Gd administration
- T2: microcystic components are hyperintense on T2
General differential considerations include:
- fibrous dysplasia
- ossifying fibroma
- osteomyelitis (around skull base)
- bone metastasis(es)
In contrast with arrested pneumatisation, all of these conditions lack the presence of internal fat or usually show signs of mass effect on the surrounding structures.
Arrested pneumatisation can be diagnosed when a lesion fulfils the following criteria:
- the lesion must be located at a site of normal pneumatisation or of recognised accessory pneumatisation
- the lesion must be non-expansile with sclerotic, well-circumscribed margins
- the lesion should show fatty content
- on CT, internal curvilinear calcifications should be present
- any associated skull base foramina should retain a normal appearance
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