Barium peritonitis

Last revised by Andrew Murphy on 23 Mar 2023

Barium peritonitis is a rare complication of gastrointestinal barium studies, and occurs when there is gastrointestinal tract perforation and spillage of barium contrast agent into the peritoneal cavity resulting in peritonitis, granuloma and stone formation 1.


Barium sulfate in the peritoneal cavity is treated as a foreign body with resultant immune response that has two phases 2-5:

Treatment and prognosis

Early laparotomy and washout/removal of barium has been shown to be beneficial. In the acute phase intravenous fluid replacement may be needed to counter the large volume of ascites and hypovolemia that can develop 2,3. Mortality is high at ~35% (range 20-53%), and is increased if there is concomitant bacterial peritonitis 2,5.

ADVERTISEMENT: Supporters see fewer/no ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.