Bartter syndrome is a rare inherited renal disorder.
Bartter syndrome is characterized by hyperplasia of the juxtaglomerular cells along with:
- metabolic alkalosis
- hypotension or normotension
- elevated plasma renin
- elevate aldosterone
- antenatal polyhydramnios
There are two subtypes of Bartter syndrome:
- classic: presents in early childhood with polyuria, polydipsia with a predisposition to dehydration
- neonatal: presents earlier
First described in 1962 by American physician Frederic Crosby Bartter (1914-1983).