Bartter syndrome

Dr Henry Knipe and A.Prof Frank Gaillard et al.

Bartter syndrome is a rare inherited renal disorder.

Bartter syndrome is characterised by hyperplasia of the juxtaglomerular cells along with:

  • hypokalemia
  • metabolic alkalosis
  • hypotension or normotension 
  • elevated plasma renin 
  • elevate aldosterone
  • antenatal polyhydramnios
Classification

There are two subtypes of Bartter syndrome: 

  • classic: presents in early childhood with polyuria, polydipsia with a predisposition to dehydration
  • neonatal: presents earlier

First described in 1962 by American physician Frederic Crosby Bartter (1914-1983).

  • Gitelman syndrome: a closely associated disorder, milder than both subtypes of Bartter's syndrome
  • Schwartz-Bartter's syndrome: a separate entity characterized by hypertonicity of urine, hyponatremia and inability to excrete water load
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Article information

rID: 5601
Section: Syndromes
Synonyms or Alternate Spellings:
  • Bartter's syndrome

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