Bickerstaff encephalitis

Bickerstaff encephalitis is a rare immune-mediated condition believed to be one of a number of conditions sharing a similar immunological mechanism, and collectively termed anti-GQ1b IgG antibody syndrome.  

Bickerstaff encephalitis is often seen following varicella zoster virus and cytomegalovirus infections 1.

Patients typically present acutely with cerebellar ataxia and external ophthalmoplegia. They may also demonstrate drowsiness, hemisensory disturbance as well as brisk reflexes and extensor plantar response 2

MRI

It transiently involves the brainstem and basal ganglia and is characterised on MRI by regions of high T2 signal with little if any enhancement. Typically these regions also demonstrate some minor restricted diffusion 1

Although symptoms are severe, the condition is usually self-limiting with a good prognosis 2

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Article Information

rID: 10719
Synonyms or Alternate Spellings:
  • Bickerstaff's brainstem encephalitis

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