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At the time the article was created Frank Gaillard had no recorded disclosures.View Frank Gaillard's current disclosures
At the time the article was last revised Tim Luijkx had no recorded disclosures.View Tim Luijkx's current disclosures
Bilateral megalencephaly refers to megalencephaly affecting both cerebral hemispheres.
- Alexander disease
- Canavan disease
- neurofibromatosis type 1 (NF1)
- Proteus syndrome
- Tay-Sachs disease
- tuberous sclerosis (TS)
- vacuolating megalencephalic leukoencephalopathy (van der Knapp disease) 1-2
The diagnosis may be suggested when the HC:AC ratio is above the 99th percentile without evidence of IUGR (i.e low AC), fetal hydrocephalus or an intracranial mass.