Calcinosis universalis is a condition characterised by long bands or sheets of symmetrical subcutaneous calcification.
It usually presents <20 years of age, and is more common in women.
- palpable calcific plaques in subcutaneous or deeper tissue
- fatigue. muscle pain, and stiffness
- possible high levels of γ-carboxyglutamic acid in tissues and urine
Calcinosis universalis manifests as long bands of symmetrical subcutaneous calcification, extending into deeper connective tissues. Tendons and ligaments may become involved.
Treatment and prognosis
No established therapy is recognised, but calcium chelates (EDTA) bisphosphonates, and steroids have been used.
- 1. Santili C, Akkari M, Waisberg G et-al. Calcinosis universalis: a rare diagnosis. J Pediatr Orthop B. 2005;14 (4): 294-8. Pubmed citation
- 2. Olsen KM, Chew FS. Tumoral calcinosis: pearls, polemics, and alternative possibilities. Radiographics. 2006;26 (3): 871-85. Radiographics (full text) - doi:10.1148/rg.263055099 - Pubmed citation