Calcinosis universalis

Calcinosis universalis is a condition characterised by long bands or sheets of symmetrical subcutaneous calcification.

It usually presents <20 years of age, and is more common in women.

  • palpable calcific plaques in subcutaneous or deeper tissue
  • fatigue, muscle pain, and stiffness
  • possible high levels of γ-carboxyglutamic acid in tissues and urine

~1/3 of cases are associated with sclerodermadermatomyositis, polymyositis, and systemic lupus erythematosus.

Calcinosis universalis manifests as long bands of symmetrical subcutaneous calcification, extending into deeper connective tissues. Tendons and ligaments may become involved.

No established therapy is recognised, but calcium chelates (EDTA) bisphosphonates, and steroids have been used.

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Article information

rID: 33788
Synonyms or Alternate Spellings:
  • Calcinosis cutis universalis

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