Chronic granulomatous disease (pulmonary manifestations)
Pulmonary manifestations of chronic granulomatous disease can be seen in approximately 80% of cases of chronic granulomatous disease, which is a disease characterized by multiple bacterial and fungal infections occurring as a result of a defect in the gene that encodes NADPH oxidase.
The most common infectious agents include Aspergillus, Staphylococcus, Burkholderia, Nocardia and Serratia species.
Many features have been described which are variable and non-specific on their own.
These include 1,3:
- regions of consolidation
- pulmonary nodules
- regions of scarring
- traction bronchiectasis
- air trapping
- pulmonary arterial enlargement
- pleural effusions
- mediastinal and hilar lymphadenopathy
- empyema formation
Contiguous extension of disease from the lungs to the pleura or chest wall can be reported in up to one-third of patients 3.
- 1. Godoy MC, Vos PM, Cooperberg PL et-al. Chest radiographic and CT manifestations of chronic granulomatous disease in adults. AJR Am J Roentgenol. 2008;191 (5): 1570-5. doi:10.2214/AJR.07.3482 - Pubmed citation
- 2. Esfandbod M, Kabootari M. Images in clinical medicine. Chronic granulomatous disease. N. Engl. J. Med. 2012;367 (8): 753. doi:10.1056/NEJMicm1106350 - Pubmed citation
- 3. Khanna G, Kao SC, Kirby P et-al. Imaging of chronic granulomatous disease in children. Radiographics. 2005;25 (5): 1183-95. doi:10.1148/rg.255055011 - Pubmed citation