Chronic granulomatous disease (pulmonary manifestations)
Pulmonary manifestations of chronic granulomatous disease can be seen approximately 80% of cases of chronic granulomatous disease, which is a disease characterised by multiple bacterial and fungal infections occurring as a result of a defect in the gene that encodes NADPH oxidase.
The most common infectious agents include Aspergillus, Staphylococcus, Burkholderia, Nocardia and Serratia species.
CT - HRCT chest
Many features have been described which are variable and nonspecific on their own.
These include 1,3:
- regions of consolidation
- pulmonary nodules
- regions of scarring
- traction bronchiectasis
- air trapping
- pulmonary arterial enlargement
- pleural effusions
- mediastinal and hilar lymphadenopathy
- empyema formation
Contiguous extension of disease from the lungs to the pleura or chest wall can be reported in up to one-third of patients 3.
- 1. Godoy MC, Vos PM, Cooperberg PL et-al. Chest radiographic and CT manifestations of chronic granulomatous disease in adults. AJR Am J Roentgenol. 2008;191 (5): 1570-5. doi:10.2214/AJR.07.3482 - Pubmed citation
- 2. Esfandbod M, Kabootari M. Images in clinical medicine. Chronic granulomatous disease. N. Engl. J. Med. 2012;367 (8): 753. doi:10.1056/NEJMicm1106350 - Pubmed citation
- 3. Khanna G, Kao SC, Kirby P et-al. Imaging of chronic granulomatous disease in children. Radiographics. 2005;25 (5): 1183-95. doi:10.1148/rg.255055011 - Pubmed citation