The musculoskeletal manifestations of cystic fibrosis are uncommon compared to the well known respiratory manifestations.
Symptoms are non-specific and include joint pain, joint swelling, back pain, and myalgia. These may mimic rheumatic symptoms, however, they do not meet the criteria for rheumatoid arthritis or other connective tissue disorders.
Musculoskeletal manifestations of cystic fibrosis include 1,2:
- low bone mineral density
- short stature
- cystic fibrosis arthropathy (~5%)
- hypertrophic osteoarthropathy (~5%)
- finger clubbing
Treatment and prognosis
The severity of the findings increases with the age of the patient as well as the severity of cystic fibrosis.
- 1. Botton E, Saraux A, Laselve H, Jousse S, Le Goff P. Musculoskeletal manifestations in cystic fibrosis. Joint, bone, spine : revue du rhumatisme. 70 (5): 327-35. Pubmed
- 2. Turner MA, Baildam E, Patel L, David TJ. Joint disorders in cystic fibrosis. Journal of the Royal Society of Medicine. 90 Suppl 31: 13-20. Pubmed