Diffuse uterine leiomyomatosis

Last revised by Mostafa Elfeky on 9 Feb 2023

Diffuse uterine leiomyomatosis is a benign and extremely rare condition in which the uterus is symmetrically enlarged as a result of the almost complete replacement of the myometrium by innumerable poorly defined, confluent leiomyomatous nodules. 

Initial symptoms of diffuse uterine leiomyomatosis usually are abdominal pain and abnormal uterine bleeding. Similar to uterine leiomyomas, patients with leiomyomatosis can present with menorrhagia, dysmenorrhea, abdominal pain, infertility, and pelvic pressure.

The exact etiology of these neoplasms is incompletely understood. 

  • is the method of choice

  • the uterus appears diffusely enlarged showing multiple innumerable ill-defined leiomyomas without discrete margins

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Cases and figures

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