Elevated vitamin B12 (marker)
Citation, DOI, disclosures and article data
Citation:
Bell D, Weerakkody Y, Elevated vitamin B12 (marker). Reference article, Radiopaedia.org (Accessed on 09 Mar 2025) https://doi.org/10.53347/rID-64052
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rID:
64052
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Disclosures:
At the time the article was created Daniel J Bell had no recorded disclosures.
View Daniel J Bell's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Daniel J Bell had no recorded disclosures.
View Daniel J Bell's current disclosures
Revisions:
4 times, by
2 contributors -
see full revision history and disclosures
Systems:
Sections:
Synonyms:
- Hypercobalaminaemia
- Hypercobalaminemia
- Hypervitaminosis B12
- Increased vitamin B12
- Elevated hydroxocobalamin
- Hyperhydroxocobalaminaemia
- Hyperhydroxocobalaminemia
- Hyperhydroxycobalaminaemia
- Hyperhydroxycobalaminemia
Elevated vitamin B12 (also known as hypervitaminosis B12 or hypercobalaminemia) is most important as a diagnostic and prognostic marker for malignant disease 1,3.
Very high serum levels of vitamin B12, following dietary megadosing, does not seem to have any observable deleterious effects 2.
References
- 1. Arendt JF, Farkas DK, Pedersen L, Nexo E, Sørensen HT. Elevated plasma vitamin B12 levels and cancer prognosis: A population-based cohort study. (2016) Cancer epidemiology. 40: 158-65. doi:10.1016/j.canep.2015.12.007 - Pubmed
- 2. Takahashi K, Tsukamoto S, Kakizaki Y, Saito K, Ohkohchi N, Hirayama K. Hypercobalaminemia induced by an energy drink after total gastrectomy: a case report. (2013) Journal of rural medicine : JRM. 8 (1): 181-5. doi:10.2185/jrm.8.181 - Pubmed
- 3. Arendt JF, Pedersen L, Nexo E, Sørensen HT. Elevated plasma vitamin B12 levels as a marker for cancer: a population-based cohort study. (2013) Journal of the National Cancer Institute. 105 (23): 1799-805. doi:10.1093/jnci/djt315 - Pubmed
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