Follicular lymphoma

Follicular lymphoma is a subtype of non-Hodgkin lymphoma (NHL) and is, in fact, the most common type.

Estimated to account for ~45% of all NHL cases 1. Higher rates in North America and Europe 4

Nodal effacement by closely packed follicles containing small cleaved cells without nucleoli (centrocytes) and larger non-cleaved cells with moderate cytoplasm, open chromatin and multiple nucleoli (centroblasts).

Follicolar lymphoma is categorized into grades according to the number of centroblasts per high-power fields(hpf) as follows5:

  • grade 1: 0-5 centroblasts per hpf
  • grade 2: 6-15 centroblasts per hpf
  • grade 3: >15 centroblasts per hpf
Markers
  • CD10: positive
  • CD5: negative
  • CD20: positive
Genetics

Translocation t(14;18) is found in the majority of patients with follicolar lymphoma. 

Complications

Transformation to a more aggressive type of NHL.

It is often indolent yet incurable with a high prevalence of residual mass post treatment 2.

Lymphoma
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Article information

rID: 12610
Section: Pathology
Synonyms or Alternate Spellings:
  • Follicular non Hodgkin lymphoma

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Cases and figures

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    Case 2: right hilum
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