Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Hacking C, Knipe H, Hepascore. Reference article, Radiopaedia.org (Accessed on 30 Mar 2025) https://doi.org/10.53347/rID-46945
Hepascore is a biochemical severity scoring system based on liver function tests in predicting the extent of liver fibrosis/cirrhosis in patients with hepatitis C infection. Hepascore may also be applicable to other liver diseases and is being trialed for steatotic liver disease and hepatitis B infection.
The following markers are analyzed:
serum bilirubin
serum gamma glutamyl transferase
serum alpha 2 macroglobulin
serum hyaluronic acid levels
These markers along with age and sex are applied to an equation and a score of between 0 and 1.0 is calculated:
<0.50: significant fibrosis is absent
≥0.50: significant fibrosis present
<0.84: cirrhosis is absent
≥0.84: cirrhosis is likely present
See also
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1. Becker L, Salameh W, Sferruzza A et-al. Validation of hepascore, compared with simple indices of fibrosis, in patients with chronic hepatitis C virus infection in United States. Clin. Gastroenterol. Hepatol. 2009;7 (6): 696-701. Pubmed citation
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2. Becker L, Salameh W, Sferruzza A et-al. Validation of hepascore, compared with simple indices of fibrosis, in patients with chronic hepatitis C virus infection in United States. Clin. Gastroenterol. Hepatol. 2009;7 (6): 696-701. Pubmed citation
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3. Adams LA, Bulsara M, Rossi E et-al. Hepascore: an accurate validated predictor of liver fibrosis in chronic hepatitis C infection. Clin. Chem. 2005;51 (10): 1867-73. doi:10.1373/clinchem.2005.048389 - Pubmed citation
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4. Lee SS, Moreau R. Cirrhosis: A Practical Guide to Management. Wiley-Blackwell. ISBN:B00R1QXT1S. Read it at Google Books - Find it at Amazon
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