Hereditary multiple diaphyseal sclerosis

Hereditary multiple diaphyseal sclerosis, also known as Ribbing disease, is a rare sclerosing dysplasia. 

It is more common in females and typically occurs in middle-aged individuals1-2.

It may be painful or asymptomatic. 

Ribbing disease predominantly involves the diaphysis of long tubular bones, most commonly the tibia and femur2. The epiphyses are spared1. The skull is generally not involved1.

It can be unilateral or bilateral 1-2

  • intramedullary sclerosis2
  • cortical thickening and sclerosis at the periosteal and endosteal surface1
  • similar to radiograph findings
  • no periosteal reaction or soft tissue component 2
  • areas of sclerosis correspond to low signal intensity on T1WI 2
  • short inversion time inversion recovery (STIR) may show high signal intensity due to marrow oedema
  • increased uptake on Tc-99 m bone scan

The condition was first reported by Ribbing3 in 1949.

Possible imaging differential considerations include






Share article

Article information

rID: 51719
Synonyms or Alternate Spellings:
  • Ribbing disease
  • Multiple diaphyseal sclerosis
  • Ribbing's disease

Support Radiopaedia and see fewer ads

Cases and figures

  • Drag
    Case 1
    Drag here to reorder.
  • Updating… Please wait.

    Alert accept

    Error Unable to process the form. Check for errors and try again.

    Alert accept Thank you for updating your details.