Juxtaglomerular cell tumour

Juxtaglomerular cell tumour (JGCT) is an infrequent renal tumour of the juxtaglomerular cells. These cells secrete renin and often cause severe hypertension and hypokalaemia.

JGCT affects all age groups, but is most common in adolescents and young adults, with peak prevalence in the second and third decades of life. JGCT has a female predominance.

Patients with JGCT present with headaches, dizziness, double vision, retinopathy, nausea/vomiting and polyuria and most of these may be attributed to hypertension or hypokalemia.

JGCT is often well circumscribed, yellow to gray-tan in colour, with a complete or partial fibrous capsule usually observed. Histologically, it consists of solid sheets of closely packed round to polygonal cells.

Imaging findings are variable.

  • hypoechoic mass
  • variable density with moderate enhancement during late phase after contrast administration

Reported signal characteristics include

  • T1: iso-signal intensity
  • T2: high-signal intensity 

Complete tumour resection by radical or partial nephrectomy is the best treatment for JGCT. Anti-hypertensive agents can be used to manage hypertension until definitive therapy is planned.

JGCT was originally described in 1967 by Robertson et al, but first named by Kihara et al. in 1968. Approximately 100 case reports have been published.

On imaging consider other renal tumours such as

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Article information

rID: 33128
Section: Pathology
Synonyms or Alternate Spellings:
  • Juxtaglomerular cell tumor
  • Juxtaglomerular cell tumor (JGCT)
  • Juxtaglomerular cell tumours
  • Juxtaglomerular cell tumors

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