Large bowel lymphoma
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At the time the article was created Henry Knipe had no recorded disclosures.View Henry Knipe's current disclosures
At the time the article was last revised Mohammad Taghi Niknejad had no financial relationships to ineligible companies to disclose.View Mohammad Taghi Niknejad's current disclosures
Large bowel (colorectal) lymphoma is a very rare tumor, accounting for <0.5% of primary colorectal malignancies, ~1.5% of all lymphomas, and ~15% of gastrointestinal lymphomas. Large bowel lymphoma differs from gastric and small bowel lymphoma in clinical presentation, management, and prognosis.
Most commonly occurs in patients in their 40s to 60s, with increasing incidence with age. There is a slight male predominance (M:F = 1.5:1) 2.
As with other colorectal tumors, primary symptoms are weight loss, pain and, less commonly, per rectal bleeding 2. Large bowel obstruction and perforation are rare.
Diffuse large B-cell lymphoma is the most common subtype (~65%) of large bowel lymphoma. Less common subtypes include mucosa-associated lymphoid tissue (MALT) lymphoma and mantle cell lymphoma (MCL) 5.
The underlying etiology is unknown but an infective/inflammatory pathogenesis is suspected as there is higher incidence in patients with HIV/AIDS, inflammatory bowel disease, and post-transplantation immunosuppression 1.
The majority (~70%) of large bowel lymphomas occur in the right colon 2.
Compared to colorectal adenocarcinoma, lymphoma affects longer and multiple colonic segments 4, mostly characterized by circumferential wall thickening.
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