Weerakkody Y, Hamidi H, Ribeiro N, et al. Loss of the insular ribbon sign. Reference article, Radiopaedia.org (Accessed on 29 Sep 2023) https://doi.org/10.53347/rID-17939
The loss of the insular ribbon sign refers to a loss of definition of the gray-white interface in the lateral margin of the insular cortex ("insular ribbon") and is considered an early CT sign of MCA infarction.
The insular cortex is more susceptible to ischemia following MCA occlusion than other portions of the MCA territory because it has the least potential for collateral supply from the anterior cerebral and posterior cerebral arteries.
1. Truwit CL, Barkovich AJ, Gean-marton A et-al. Loss of the insular ribbon: another early CT sign of acute middle cerebral artery infarction. Radiology. 1990;176 (3): 801-6. Radiology (abstract) - Pubmed citation
2. Nakano S, Iseda T, Kawano H et-al. Correlation of early CT signs in the deep middle cerebral artery territories with angiographically confirmed site of arterial occlusion. AJNR Am J Neuroradiol. 2001;22 (4): 654-9. AJNR Am J Neuroradiol (full text) - Pubmed citation
3. Sarikaya B, Provenzale J. Frequency of various brain parenchymal findings of early cerebral ischemia on unenhanced CT scans. Emerg Radiol. 2010;17 (5): 381-90. doi:10.1007/s10140-010-0870-2 - Pubmed citation