Low phospholipid-associated cholelithiasis syndrome
Citation, DOI, disclosures and article data
Citation:
Knipe H, Low phospholipid-associated cholelithiasis syndrome. Reference article, Radiopaedia.org (Accessed on 30 Mar 2025) https://doi.org/10.53347/rID-52070
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rID:
52070
Article created:
Disclosures:
At the time the article was created Henry Knipe had no recorded disclosures.
View Henry Knipe's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Henry Knipe had the following disclosures:
- Radiopaedia Events Pty Ltd, Speaker fees (past)
- Integral Diagnostics, Shareholder (ongoing)
- Micro-X Ltd, Shareholder (ongoing)
These were assessed during peer review and were determined to not be relevant to the changes that were made.
View Henry Knipe's current disclosures
Revisions:
3 times, by
1 contributor -
see full revision history and disclosures
Systems:
Sections:
Synonyms:
- LPAC
Low phospholipid-associated cholelithiasis (LPAC) syndrome is one of the syndromes associated with ABCB4/MDR3 mutation. Characteristics of this syndrome include 1,2:
- intrahepatic microlithiasis/sludge
- symptomatic cholesterol stones with early onset (<40 years)
- recurrent symptoms post cholecystectomy
- successful treatment (i.e. symptom resolution) with ursodeoxycholic acid (UDCA)
References
- 1. Pasmant E, Goussard P, Baranes L et al. First Description of ABCB4 Gene Deletions in Familial Low Phospholipid-Associated Cholelithiasis and Oral Contraceptives-Induced Cholestasis. Eur J Hum Genet. 2011;20(3):277-82. doi:10.1038/ejhg.2011.186 - Pubmed
- 2. Sundaram S & Sokol R. The Multiple Facets of ABCB4 (MDR3) Deficiency. Curr Treat Options Gastroenterol. 2007;10(6):495-503. doi:10.1007/s11938-007-0049-4 - Pubmed
- 3. Rosmorduc O & Poupon R. Low Phospholipid Associated Cholelithiasis: Association with Mutation in the MDR3/ABCB4 Gene. Orphanet J Rare Dis. 2007;2(1):29. doi:10.1186/1750-1172-2-29 - Pubmed
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