Mixed sclerosing bone dysplasia
Citation, DOI, disclosures and article data
At the time the article was created Craig Hacking had no recorded disclosures.View Craig Hacking's current disclosures
At the time the article was last revised Francis Fortin had no recorded disclosures.View Francis Fortin's current disclosures
Mixed sclerosing bone dysplasia (MSBD) is a combined and highly variable bone sclerosing spectrum with shared features of 3 radiological entities:
Some authors propose these 3 conditions are within the same sclerosing spectrum 5. Little is known about this overlap dysplasia, which is proposed to be due to abnormal endochondral and intramembranous ossification. It may share an underlying etiology and loss of function mutations in the LEMD3 gene has been proposed 6.
It has features of all 3 components but is highly variable and its etiology may be inherited or sporadic.