Last chance for 25% off our online courses and all-access passes! EXPLORE OUR LIBRARY

Mixed sclerosing bone dysplasia

Mixed sclerosing bone dysplasia (MSBD) is a combined and highly variable bone sclerosing spectrum with shared features of 3 radiological entities:

Some authors propose these 3 conditions are within the same sclerosing spectrum 5. Little is known about this overlap dysplasia, which is proposed to be due to abnormal endochondral and intramembranous ossification. It may share an underlying etiology and loss of function mutations in the LEMD3 gene has been proposed 6.

It has features of all 3 components but is highly variable and its etiology may be inherited or sporadic.

Article information

rID: 69894
Synonyms or Alternate Spellings:
  • MSBD

ADVERTISEMENT: Supporters see fewers/no ads

Cases and figures

  • Case 1: osteopathia striata
    Drag here to reorder.
  • Case 2: melorheostosis
    Drag here to reorder.
  • Case 3: osteopoikilosis
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.