Neuroblastoma (craniocerebral metastases)

Craniocerebral neuroblastoma metastases usually involve the calvaria, orbits, skull base and the dura.

Please refer to the article neuroblastoma for a general discussion on this entity. 

In children, neuroblastoma is the most common cause of orbital metastases 4.

  • proptosis
  • periorbital ecchymosis ("racoon eyes")
  • palpable calvarial masses
  • spiculated periorbital bone mass, typically involving the roof or lateral wall/sphenoid wings
  • "hair on end" spiculated periostitis of orbits and skull usually associated with bone destruction
  • sutural separation: non-uniform sutural separation with indistinct suture margins
  • cranial metastasis nearly always extradural (may mimic epidural or subdural hematoma)
  • T1: hypointense to muscles
  • T2: heterogeneous usually hyperintense to muscles
  • T1 C+ (Gd): vigorously enhances, may be heterogeneous
  • MRV: may narrow or invade adjacent dural sinuses
  • MIBG (meta-iodo benzyl guanidine): avid uptake by neural crest tumors
  • TC-99-m-MDP: shows increased uptake due to the calcium metabolism of the tumor
  • PET: shows high sensitivity and specificity for recurrent tumors

Imaging differential considerations include:

Article information

rID: 39279
Synonyms or Alternate Spellings:
  • Craniocerebral neuroblastoma metastases
  • Metastatic neuroblastoma to the brain
  • Metastatic CNS neuroblastoma

ADVERTISEMENT: Supporters see fewer/no ads

Cases and figures

  • Case 1
    Drag here to reorder.
  • Case 1: with spiculated periostitis "hair on end"
    Drag here to reorder.
  • Case 2
    Drag here to reorder.
  • Case 3
    Drag here to reorder.
  • Case 4
    Drag here to reorder.
  • Case 5
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.