Neuroblastoma (craniocerebral metastases)

Craniocerebral neuroblastoma metastases usually involve the calvaria, orbits, skull base and the dura.

Please refer to the article neuroblastoma for a general discussion on this entity. 

  • proptosis
  • periorbital ecchymosis "raccoon eyes"
  • palpable calvarial masses
CT
  • spiculated periorbital bone mass, typically involving the roof or lateral wall/sphenoid wings
  • "hair on end" spiculated periostitis of orbits and skull usually associated with bone destruction
  • sutural separation: non-uniform sutural separation with indistinct sutures margins
  • cranial metastasis nearly always extradural (may mimic epidural or subdural hematoma)
MRI
  • T1: hypointense to muscles
  • T2: heterogeneous usually hyperintense to muscles
  • T1 C+ (Gd): vigorously enhances, may be heterogeneous
  • MRV: may narrow or invade adjacent dural sinuses
Nuclear medicine
  • MIBG (meta-iodo benzyl guanidine): avid uptake by neural crest tumours
  • TC-99-m-MDP: shows increased uptake from calcium metabolism of tumour
  • PET: shows high sensitivity and specificity for recurrent tumours

Imaging differential considerations include:

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Article information

rID: 39279
Section: Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • Metastatic neuroblastoma to the brain
  • Metastatic CNS neuroblastoma

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Cases and figures

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    Case 1
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    Case 1: with spiculated periostitis "hair on end"
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