Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Luong D, Neuron-specific enolase. Reference article, Radiopaedia.org (Accessed on 23 Mar 2025) https://doi.org/10.53347/rID-83927
Disclosures:
At the time the article was last revised Henry Knipe had the following disclosures:
- Micro-X Ltd, Shareholder (past)
These were assessed during peer review and were determined to
not be relevant to the changes that were made.
View Henry Knipe's current disclosures
Neuron-specific enolase (NSE) is a cell-specific isoenzyme of the glycolytic enzyme enolase. It is sometimes considered as a tumor marker.
Pathology
Elevated neuron-specific enolase levels have been shown to occur in association with the following
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tumors
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non-malignant conditions
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1. Isgr M et.al. Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical Aspects. (2020) Advances in experimental medicine and biology. doi:10.1007/978-94-017-7215-0_9 - Pubmed
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2. Kaiser E, Kuzmits R, Pregant P, Burghuber O, Worofka W. Clinical biochemistry of neuron specific enolase. (1989) Clinica chimica acta; international journal of clinical chemistry. 183 (1): 13-31. doi:10.1016/0009-8981(89)90268-4 - Pubmed
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3. J Collazos, C Esteban, A Fernández, J Genollá. Measurement of the serum tumor marker neuron-specific enolase in patients with benign pulmonary diseases. (2012) American journal of respiratory and critical care medicine. doi:10.1164/ajrccm.150.1.8025740
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