Octreotide scintigraphy
Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Baba Y, Thibodeau R, et al. Octreotide scintigraphy. Reference article, Radiopaedia.org (Accessed on 21 Mar 2025) https://doi.org/10.53347/rID-9705
rID:
9705
Article created:
Disclosures:
At the time the article was created Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Henry Knipe had the following disclosures:
- Micro-X Ltd, Shareholder (past)
These were assessed during peer review and were determined to not be relevant to the changes that were made.
View Henry Knipe's current disclosures
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22 times, by
12 contributors -
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Synonyms:
- Octreotide scan
- In-111 Octreoscan
- Octreoscan
Octreotide scintigraphy uses 111In-labelled octreotide, a somatostatin analogue; it is also known as Octreoscan, a brand name for 111In-labelled pentetreotide. Pentetreotide is a DTPA-conjugated form of octreotide, originally manufactured by Mallinckrodt Nuclear Medicine LLC, which now forms part of Curium.
The radiotracer is characterised by a high bond affinity with the somatostatin receptor 2 (SST2). It penetrates the cell by endocytosis, first held by lysosomes and then transferred to the nucleus 4,5.
It is particularly useful for assessing neuroendocrine tumours, and the Krenning Score is used to grade these, most commonly for peptide receptor radionuclide therapy (PRRT) planning.
Examples include:
Certain non-neuroendocrine tumours can also show uptake in an Octreoscan. Examples include:
Also, certain autoimmune or granulomatous diseases (for example sarcoidosis) may occasionally show octreotide uptake by overexpression of somatostatin receptors 6-8.
Quiz questions
References
- 1. Whiteman M, Serafini A, Telischi F, Civantos F, Falcone S. 111In Octreotide Scintigraphy in the Evaluation of Head and Neck Lesions. AJNR Am J Neuroradiol. 1997;18(6):1073-80. PMC8337293 - Pubmed
- 2. Ramage J, Williams R, Buxton-Thomas M. Imaging Secondary Neuroendocrine Tumours of the Liver: Comparison of I123 Metaiodobenzylguanidine (MIBG) and In111-Labelled Octreotide (Octreoscan). QJM. 1996;89(7):539-42. doi:10.1093/qjmed/89.7.539 - Pubmed
- 3. Guitera-Rovel P, Lumbroso J, Gautier-Gougis M et al. Indium-111 Octreotide Scintigraphy of Merkel Cell Carcinomas and Their Metastases. Ann Oncol. 2001;12(6):807-11. doi:10.1023/a:1011142410535 - Pubmed
- 4. Hornick C, Anthony C, Hughey S, Gebhardt B, Espenan G, Woltering E. Progressive Nuclear Translocation of Somatostatin Analogs. J Nucl Med. 2000;41(7):1256-63. - Pubmed
- 5. Janson E, Westlin J, Ohrvall U, Oberg K, Lukinius A. Nuclear Localization of 111In After Intravenous Injection of [111In-DTPA-D-Phe1]-Octreotide in Patients with Neuroendocrine Tumors. J Nucl Med. 2000;41(9):1514-8. - Pubmed
- 6. Dalm V, van Hagen P, Krenning E. The Role of Octreotide Scintigraphy in Rheumatoid Arthritis and Sarcoidosis. Q J Nucl Med. 2003;47(4):270-8. - Pubmed
- 7. van Hagen P, Krenning E, Kwekkeboom D et al. Somatostatin and the Immune and Haematopoetic System; a Review. Eur J Clin Invest. 1994;24(2):91-9. doi:10.1111/j.1365-2362.1994.tb00972.x - Pubmed
- 8. ten Bokum A, Hofland L, van Hagen P. Somatostatin and Somatostatin Receptors in the Immune System: A Review. Eur Cytokine Netw. 2000;11(2):161-76. - Pubmed
Incoming Links
Articles:
- Pancreatic neuroendocrine tumours
- Carotid body tumor
- Gastrinoma
- Hepatic neuroendocrine tumour
- Digestive system neuroendocrine tumours
- Phaeochromocytoma
- Neuroendocrine neoplasm
- Incidental thyroid nodule
- Medical abbreviations and acronyms (S)
- Lutetium-177 dotatate
- Paragangliomas of the head and neck
- Gallium-68 DOTATATE
- Bronchial carcinoid tumour
- Krenning score of neuroendocrine tumour uptake
Cases:
Multiple choice questions:
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