Opsomyoclonus (dancing eyes-dancing feet syndrome) is a clinical syndrome which has strong association with neuroblastoma.
The “opso-“ refers to the presence of intermittent jerky eye movements (dancing eyes) and the “myoclonus” to myoclonic jerks and cerebellar ataxia (dancing feet). Although only 2% of patients with neuroblastoma present with opsomyoclonus, up to 50% of patients with opsomyoclonus are ultimately found to have a neuroblastoma1.
The implication is that a child found to have opsomyoclonus must be investigated thoroughly for an otherwise occult neuroblastoma.
Treatment and prognosis
If a neuroblastoma is found in a patient with opsomyoclonus, it is generally small with relatively favourable histology and the prognosis, in terms of survival, is very good. The neurologic symptoms may be treated with corticosteroids and/or ACTH, but often persist despite the medical treatment and surgical resection 2.
- 1. 1 Farrelly C, Daneman A, Chan HS et-al. Occult neuroblastoma presenting with opsomyoclonus: utility of computed tomography. AJR Am J Roentgenol. 1984;142 (4): 807-10. AJR Am J Roentgenol (abstract) - Pubmed citation
- 2. Mitchell WG, Davalos-gonzalez Y, Brumm VL et-al. Opsoclonus-ataxia caused by childhood neuroblastoma: developmental and neurologic sequelae. Pediatrics. 2002;109 (1): 86-98. Pediatrics (full text) - Pubmed citation
- 3. Matthay KK, Blaes F, Hero B et-al. Opsoclonus myoclonus syndrome in neuroblastoma a report from a workshop on the dancing eyes syndrome at the advances in neuroblastoma meeting in Genoa, Italy, 2004. Cancer Lett. 2005;228 (1-2): 275-82. doi:10.1016/j.canlet.2005.01.051 - Pubmed citation
- 4. Pohl KR, Pritchard J, Wilson J. Neurological sequelae of the dancing eye syndrome. Eur. J. Pediatr. 1996;155 (3): 237-44. - Pubmed citation