Sarcomatoid renal cell carcinoma
Sarcomatoid renal cell carcinomas (sRCC) may develop when one of the more common subtypes of renal cell carcinoma degenerates into a sarcoma.
On imaging, they are generally large masses, with irregular contours, and malignant-appearing, but do not have specific imaging features.
The sarcomatoid variant has been estimated to occur in ~16% of cases of advanced renal cell cancer. Approximately 5% of renal tumours my contain elements of sarcomatoid transformation.
Highly aggressive variant associated with metastatic disease. ~90% are symptomatic at presentation 4.
Once a separate category, it is now known that sRCC can develop from all other histologic subtypes. It demonstrates spindle cells, high cellularity, and cellular atypia. It is associated with extensive chromosomal rearrangements 2.
It has been described as "the final common dedifferentiation pathway" of renal tumours 3.
A diagnosis of sRCC is based on histology and it currently has no specific imaging features. Its appearance is similar to advanced renal cell carcinoma, although sRCC has a tendency to be necrotic.
- tend to be large at diagnosis (~9-10 cm)
- tends to present with metastatic disease (>45%)
MRI may show a heterogeneous renal mass with areas of low T2 signal intensity, but this appearance lacks specificity 6.
Treatment and prognosis
Currently, the biology of sRCC is poorly understood. Since it generally develops from advanced renal cell cancer and often presents with metastases, it is difficult to treat effectively. Prognosis is worse than equivalent size and stage non-sarcomatous RCC.
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- 6. Takeuchi M, Kawai T, Suzuki T et-al. MRI for differentiation of renal cell carcinoma with sarcomatoid component from other renal tumor types. Abdom Imaging. 2015;40 (1): 112-9. doi:10.1007/s00261-014-0185-y - Pubmed citation