Solid pseudopapillary tumour of the pancreas

Solid pseudopapillary tumours (SPT) of the pancreas are rare (usually benign) pancreatic tumours.

The tumour has been referred to with multiple different names, including:

  • solid pseudopapillary tumour (SPT) of the pancreas
  • solid pseudopapillary neoplasm (SPN)
  • solid pseudopapillary epithelial neoplasm (SPEN)
  • papillary cystic neoplasm of the pancreas
  • Hamoudi tumour
  • Gruber-Frantz tumour (or just Frantz tumour)

They are extremely rare and thought to account for 1-2% of exocrine pancreatic tumours. They tend to present in young non-Caucasian females around the 2nd and 3rd decades of life.

Most patients are asymptomatic at diagnosis. They may occasionally present with a gradually enlarging abdominal mass or vague abdominal pain.

The tumours frequently contain varying amounts of necrosis, haemorrhage, and cystic change. Lesions can be large at time of diagnosis (median size ~8 cm) 2.

There is a greater predilection to occur at pancreatic tail.

Large well-defined mass with heterogeneous apperances, due to its solid and cystic composition.

Usually seen as a well-encapsulated lesion with varying solid and cystic components owing to haemorrhagic degeneration. Following IV contrast administration, enhancing solid areas are typically noted peripherally, whereas cystic spaces are usually more centrally located. Calcifications and enhancing solid areas may be present at the periphery of the mass.

Typically demonstrates a well-defined lesion. May show a pure solid consistency in ~80% of cases 6.

Reported signal characteristics include:

  • T1: low to heterogeneous signal intensity 1,6
  • T2: heterogeneous to high signal intensity 1,6
  • C+ (Gd): can show heterogeneous and slowly progressive enhancement

While most lesions are benign, ~15% can be malignant. Complete resection is associated with long-term survival even in the presence of metastatic disease.

It was first described by Frantz et al in 1959 4-5.

Pancreatic pathology
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Article information

rID: 16859
Section: Pathology
Synonyms or Alternate Spellings:
  • Solid pseudopapillary tumour of the pancreas
  • Solid pseudopapillary tumour (SPT) of pancreas
  • SPT pancreas
  • SPT of pancreas
  • Hamoudi tumor
  • Hamoudi tumour
  • SPEN
  • Solid pseudopapillary epithelial neoplasm
  • Gruber-Frantz tumour
  • Gruber-Frantz tumor
  • Frantz tumour
  • Frantz tumor
  • Frantz's tumor
  • Frantz's tumour

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