Triangle of Guillain and Mollaret

Dr Henry Knipe and A.Prof Frank Gaillard et al.

The triangle of Guillain and Mollaret, also known as the dentatorubro-olivary pathway, has three corners 1:

  1. red nucleus
  2. inferior olivary nucleus
  3. contralateral dentate nucleus

Rubro-olivary fibres descend from the parvocellular division of each red nucleus along the central segmental tracts to reach the capsule (amiculum) of the ipsilateral inferior olivary nucleus (ION). From the ION, olivo-cerebellar fibres cross the contralateral inferior cerebellar peduncle to reach cerebellar cortex, then pass from cerebellar cortex to the contralateral dentate nucleus. Dentatorubral fibres then ascend via the contralateral superior cerebellar peduncle, decussate in the midbrain, and return to the original red nucleus 1

Note that no direct connecting tract is present between the inferior olivary nucleus and contralateral dentate nucleus 1

Related pathology

Lesions of the superior cerebellar peduncle lead to contralateral hypertrophic olivary degeneration. Lesions of the central segmental tract lead to ipsilateral hypertrophic olivary degeneration. Lesions of the olive-cerebellar fibres lead to contralateral cerebellar atrophy.

Potential clinical manifestations include palatal myoclonus and a dentatorubral upper limb tremor (Holmes tremor).

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Article information

rID: 2205
Section: Anatomy
Synonyms or Alternate Spellings:
  • Myoclonic triangle
  • Dentato-rubral-olivary pathway
  • Dentatorubro-olivary pathway

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Cases and figures

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    Figure 1: triangle of Guillain and Mollaret
    Drag here to reorder.
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