Dentate nucleus
Citation, DOI, disclosures and article data
Citation:
Gaillard F, Campos A, Hacking C, et al. Dentate nucleus. Reference article, Radiopaedia.org (Accessed on 26 Jan 2025) https://doi.org/10.53347/rID-49083
Permalink:
rID:
49083
Article created:
Disclosures:
At the time the article was created Frank Gaillard had no recorded disclosures.
View Frank Gaillard's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Arlene Campos had no financial relationships to ineligible companies to disclose.
View Arlene Campos's current disclosures
Revisions:
9 times, by
7 contributors -
see full revision history and disclosures
Systems:
Sections:
Synonyms:
- Dentate nuclei
The dentate nucleus is the largest and most lateral of the cerebellar nuclei, located medially within each cerebellar hemisphere, just posterolateral to the fourth ventricle 1.
It is part of the triangle of Guillain and Mollaret, connected to the contralateral red nucleus via the superior cerebellar peduncle (rubrodentate fibers) 2.
Radiographic features
MRI
The dentate nucleus is most easily identified on T2 and particularly T2* weighted sequences (e.g. SWI) as an undulating semicircular structure, the opening facing the midline. It is usually difficult to identify on T1 weighted images.
There has been significant interest in gadolinium deposition in the dentate nucleus, which becomes readily visible on T1 weighted images in patients who have received multiple doses of gadolinium containing contrast agents 3.
References
- 1. Gray's Anatomy E-Book. (2015) ISBN: 9780702068515 - Google Books
- 2. Wein S, Yan B, Gaillard F. Hypertrophic Olivary Degeneration Secondary to Pontine Haemorrhage. J Clin Neurosci. 2015;22(7):1213-4. doi:10.1016/j.jocn.2015.02.005 - Pubmed
- 3. Roberts D, Chatterjee A, Yazdani M et al. Pediatric Patients Demonstrate Progressive T1-Weighted Hyperintensity in the Dentate Nucleus Following Multiple Doses of Gadolinium-Based Contrast Agent. AJNR Am J Neuroradiol. 2016;37(12):2340-7. doi:10.3174/ajnr.A4891 - Pubmed
- 4. Bhattacharya K, Pendharkar H, Gupta AK. Imaging of dentate nucleus pathologies; a pictorial essay. (2018) The Indian journal of radiology & imaging. 28 (2): 152-160. doi:10.4103/ijri.IJRI_290_17 - Pubmed
- 5. K.M. Bond, W. Brinjikji, L.J. Eckel, D.F. Kallmes, R.J. McDonald, C.M. Carr. Dentate Update: Imaging Features of Entities That Affect the Dentate Nucleus. (2017) American Journal of Neuroradiology. doi:10.3174/ajnr.A5138 - Pubmed
Incoming Links
Articles:
- Cerebellar nuclei
- Hippocampal calcification
- Fahr syndrome
- Superior cerebellar artery
- Cerebrotendinous xanthomatosis
- CLCN2-related leukoencephalopathy
- Alzheimer type II glia
- Phospholipase A2 associated neurodegeneration
- Neuroferritinopathy
- Triangle of Guillain and Mollaret
- Langerhans cell histiocytosis (CNS manifestations)
- Gadolinium
- Metronidazole central nervous system toxicity
- Acaeruloplasminaemia
- Cerebellum
- Cathepsin A-related arteriopathy with strokes and leukoencephalopathy (CARASAL)
- Normal intracranial calcifications
- Red nucleus
- Wilson disease (CNS manifestations)
- Shrimp sign (progressive multifocal leukoencephalopathy)
Cases:
- Neurotoxic impact of metronidazole on the central nervous system
- Hypertrophic olivary degeneration
- Dentate nucleus (Gray's illustration)
- Cerebellar mutism syndrome and pilocytic astrocytoma
- Neurofibromatosis type 1 - with optic pathway gliomas
- Vanishing white matter disease
- Radiation leukoencephalopathy
- Retained gadolinium in the brain
- Hypertrophic olivary degeneration
- Spinocerebellar ataxia
- Cerebral toxoplasmosis
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