Citation, DOI, disclosures and article data
Citation:
Knipe H, Sharma R, Bell D, Myeloma defining events (mnemonic). Reference article, Radiopaedia.org (Accessed on 08 Mar 2025) https://doi.org/10.53347/rID-70874
The myeloma defining events can be recalled using the mnemonics:
Mnemonics
CRAB
SLiM-CRAB
The CRAB and SLiM-CRAB mnemonics differentiate multiple myeloma from its precursor diseases - monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma 2,3. The SLiM criteria were added to the CRAB criteria of multiple myeloma in 2014 3.
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1. Alípio G. Ormond Filho, Bruno C. Carneiro, Daniel Pastore, Igor P. Silva, Sâmia R. Yamashita, Flávio D. Consolo, Vânia T. M. Hungria, Alex F. Sandes, Edgar G. Rizzatti, Marcelo A. C. Nico. Whole-Body Imaging of Multiple Myeloma: Diagnostic Criteria. (2019) RadioGraphics. 39 (4): 1077-1097. doi:10.1148/rg.2019180096 - Pubmed
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2. Nakaya A, Fujita S, Satake A, Nakanishi T, Azuma Y, Tsubokura Y, Hotta M, Yoshimura H, Ishii K, Ito T, Nomura S. Impact of CRAB Symptoms in Survival of Patients with Symptomatic Myeloma in Novel Agent Era. (2017) Hematology reports. 9 (1): 6887. doi:10.4081/hr.2017.6887 - Pubmed
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3. Rajkumar S, Dimopoulos M, Palumbo A et al. International Myeloma Working Group Updated Criteria for the Diagnosis of Multiple Myeloma. Lancet Oncol. 2014;15(12):e538-48. doi:10.1016/S1470-2045(14)70442-5 - Pubmed
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