Castleman disease

Case contributed by Dr Lukas Valkovic

Presentation

Elderly patient treated for uterine carcinoma and was examined for generalized lymphadenopathy suspected of dissemination of the underlying disease.

Patient Data

Age: 67
Gender: Female
CT

There are multiple enhancing small and enlarged neck, axillary and inguinal lymph nodes.

Case Discussion

Castleman disease is a rare lymphoproliferative disease that can affect various groups of lymph nodes. It must be distinguished from reactive hyperplasia and malignancy. It is the proliferation of lymph tissue (B cells), often with cytokine production. Although not a malignant disease it is very similar to lymphoma. The disease is usually associated with AIDS and may develop hemolytic anemia or non-Hodgkin lymphoma. Antiviral therapy is effective, but it can affect patients immune system.

In this particular patient this diagnosis was histologically confirmed.

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Case information

rID: 44551
Case created: 27th Apr 2016
Last edited: 16th Jul 2017
Inclusion in quiz mode: Included

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