Langerhans cell histiocytosis

Case contributed by Annalise Lang
Diagnosis certain


Chronic eczema and seborrheic dermatitis, now worsening and with vomiting, and increased thirst.

Patient Data

Age: 2 years
Gender: Male

Numerous large irregularly shaped lytic lesions throughout the skull. There is an expansile lytic lesion involving the mid-right clavicle with irregularity and callous formation.

Case Discussion

Typical skull radiograph for Langerhans cell histiocytosis, showing irregularly-shaped lytic lesions with a beveled edge appearance. Increased thirst (due to diabetes insipidus) and skin rash also fit the diagnosis of Langerhans cell histiocytosis, which confirmed by skin biopsy.

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