Sickle cell disease related osteosclerosis

Case contributed by Dr Aneta Kecler - Pietrzyk

Presentation

30 years old referred by GP with ongoing cough.

Patient Data

Age: 30
Gender: Male

Diffusely sclerotic bones (osteosclerosis) incidentally seen on PA chest radiograph performed for suspected lower respiratory tract infection. Also, multilevel H-shaped vertebrae are seen. 

Case Discussion

Osteosclerosis or diffuse increased bones density is caused by many underlying diseases including:

  • congenital, e.g. osteopetrosis (usually associated with extensive nephrocalcinosis)
  • haematological, e.g. myelofibrosis, mastocytosis (dermatographia is very characteristic for this entity) and sickle cell anaemia
  • metabolic, e.g. secondary hyperparathyroidism (renal osteodystrophy)
  • malignant, e.g. metastatic disease, most commonly from prostate or breast primary neoplasm
  • toxic, e.g. fluorosis, vitamin D hypervitaminemia

In this case, sickle cell anaemia turned out to be a cause (H-shaped vertebrae helped to narrow the differential).

PlayAdd to Share

Case information

rID: 52445
Case created: 7th Apr 2017
Last edited: 12th Apr 2017
Inclusion in quiz mode: Included

Updating… Please wait.
Loadinganimation

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.