Case contributed by Dr Abdallah Al Khateeb


Chronic cough. Chest x-ray showed an anterior mediastinal mass.

Patient Data

Age: 75 years
Gender: Male

There is a smooth anterior mediastinal mass, with mixed internal density of containing both enhancing soft tissue and cystic areas. The outline of the mass is relatively well defined. No lymphadenopathy, pleural effusion or infiltration.


MICROSCOPIC DESCRIPTION: Microscopy shows an encapsulated tumor composed of two alternating cytomorphological and histoarchitectural components.  The first component contains neoplastic epithelium forming delicate loose network, and having large polygonal cells with large
nuclei, open chromating and prominent central nucleoli, equally admixed with non-neoplastic lymphocytes. The second component exhibits vaguely solid sheets of neoplastic epithelium composed of polygonal medium-sized cells, with smaller round nuclei and prominent nucleoli, with paucity of lymphocytes. Both components show abundance of Hassall's corpuscles. There are areas of extensive tumor necrosis, small cystic space formation and cholesterol clefts. There is no marked nuclear polymorphism or significant mitotic activity.

DIAGNOSIS: Corpuscular thymoma, WHO type B3.

Case Discussion

Thymomas are a common cause of anterior mediastinal masses.

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Case information

rID: 43403
Published: 8th Mar 2016
Last edited: 17th Jun 2021
System: Chest
Inclusion in quiz mode: Included

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