Cutaneous and subcutaneous metastases are uncommon, occurring in ~5% (range 0.7-10%) of internal malignancies. Sister Mary Joseph nodule is a well known cutaneous metastases.
These metastases can come from haematogenous or lymphatic spread, or may result from seeding from a surgical procedure. Underlying primary malignancies include 1,2:
- breast cancer (most common in females)
- lung cancer (most common in males)
- malignant melanoma
- colorectal carcinoma
- head and neck cancers
- ovarian cancer
Cutaneous and subcutaneous metastases can present as multiple small, usually <2 cm, masses or as a larger infiltrative mass 1.
- 1. Juan YH, Saboo SS, Tirumani SH et-al. Malignant skin and subcutaneous neoplasms in adults: multimodality imaging with CT, MRI, and 18F-FDG PET/CT. AJR Am J Roentgenol. 2014;202 (5): W422-38. doi:10.2214/AJR.13.11424 - Pubmed citation
- 2. Manohar K, Mittal BR, Bhattacharya A et-al. Asymptomatic Distant Subcutaneous Metastases Detected by (18)F-FDG-PET/CT in a Patient with Breast Carcinoma. World J Nucl Med. 2012;11 (1): 24-5. doi:10.4103/1450-1147.98742 - Free text at pubmed - Pubmed citation