Dysmyelinating disorders
Citation, DOI, disclosures and article data
At the time the article was created Jeremy Jones had no recorded disclosures.
View Jeremy Jones's current disclosuresAt the time the article was last revised Daniel J Bell had no financial relationships to ineligible companies to disclose.
View Daniel J Bell's current disclosures- dysmyelination
- Dysmyelinating diseases
- Dysmyelinating disease
- Dysmyelinating disorder
Dysmyelinating disorders are a subset of white matter disorders characterized by abnormal myelination 1. They include numerous inherited conditions that are characterized by a defective structure and function of the myelin sheath 2.
Terminology
Dysmyelinating disorders are often thought of being synonymous with leukodystrophies, and traditionally they have been thought of as being distinct from demyelinating disorders where there is destruction or damage of previously normal myelination.
It is now apparent that many of the more common leukodystrophies (e.g. metachromatic leukodystrophy, X-linked adrenoleukodystrophy) have a significant demyelinating component 3,4.
As such it is best to think of dysmyelinating and demyelinating as describing the dominant process involved in the larger group of leukodystrophies.
References
- 1. William E. Brant, Clyde A. Helms. Fundamentals of Diagnostic Radiology. (2007) ISBN: 9780781761352 - Google Books
- 2. Richard A. Prayson. Neuropathology Review. (2008) ISBN: 9781588298959 - Google Books
- 3. Cheon J, Kim I, Hwang Y et al. Leukodystrophy in Children: A Pictorial Review of MR Imaging Features. Radiographics. 2002;22(3):461-76. doi:10.1148/radiographics.22.3.g02ma01461 - Pubmed
- 4. Thomas A. Fleisher, William T. Shearer, Anthony J. Frew et al. Clinical Immunology,Principles and Practice (Expert Consult - Online and Print),4. (2013) ISBN: 9780723436911 - Google Books
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