Fibrolipomatous hamartoma of the nerve

Radswiki et al.

A fibrolipomatous hamartoma of the nerve (also known as a neural fibrolipoma) is a benign neoplasm of nerves, resulting from anomalous growth of fibroadipose tissue of the nerve sheath.

Fibrolipomatous hamartoma may be related to hypertrophy of mature fat and fibroblasts in the epineurium

A fibrolipomatous hamartoma of the nerve can involve the median (80%), ulnar and or radial nerves and or dorsum of the hand.

Macrodactyly of the involved part can be present in ~ 66% of all cases of fibrolipomatous hamartoma of the median nerve.

A characteristic hypoechoic coaxial cabling encased by an echogenic substratum may be seen 3.

MRI features are often pathognomonic and typically shows a coaxial cable-like appearance on axial images and a spaghetti-like appearance on coronal images 2,6.

  • T1 - the neural bundles were hyperintense to muscle and the surrounding substratum was isointense to muscle 3
  • T2 - fat components are high signal and fibrous components are low signal

It is thought to have been first reported by M L Mason in 1953 5.

The lesion is benign and the preferred management of the lesion is conservative.

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Article information

rID: 13422
Tag: cases
Synonyms or Alternate Spellings:
  • Neural fibrolipoma
  • Lipofibromatous hamartoma of the nerve
  • Fibrolipomatous hamartoma of nerve

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Cases and figures

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    Case 1: classically affecting the median nerve
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    Case 2: median nerve - with coaxial cable appearance
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