Hereditary spastic paraplegia

Hereditary spastic paraplegia (HSP) refers to a heterogeneous group of neurodegenerative conditions characterised by progressive degeneration of the corticospinal tracts and posterior column of the spinal cord.

Patients often tend to have progressive lower extremity weakness and spasticity.

Genetics

Most carry an autosomal recessive inheritance.

Subtypes
MRI

Often nonspecific and variable but can include:

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Article Information

rID: 42174
Synonyms or Alternate Spellings:
  • Hereditary spastic paraplegia (HSP)
  • Hereditary spastic paraplegias

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