The ear of the lynx sign refers to abnormal T2/FLAIR cone-shaped hyperintensity at the tip of the frontal horn of the lateral ventricles in the region of forceps minor which resembles the tufts of hair crowning the ears of a lynx. This sign is seen in hereditary spastic paraplegia associated with mutations of the spastic paraparesis gene 11 (SPG11) on chromosome 15 1,2. It is a characteristic early imaging finding of hereditary spastic paraplegia with thin corpus callosum (HSP-TCC). This sign has also been described in Marchiafava-Bignami disease 3.
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- 2. B. Pascual, S.T. de Bot, M.R. Daniels, M.C. França, C. Toro, M. Riverol, P. Hedera, M.T. Bassi, N. Bresolin, B.P. van de Warrenburg, B. Kremer, J. Nicolai, P. Charles, J. Xu, S. Singh, N.J. Patronas, S.H. Fung, M.D. Gregory, J.C. Masdeu. “Ears of the Lynx” MRI Sign Is Associated with SPG11 and SPG15 Hereditary Spastic Paraplegia. (2019) American Journal of Neuroradiology. 40 (1): 199. doi:10.3174/ajnr.A5935 - Pubmed
- 3. Felipe Torres Pacheco, Milena Morais Rego, Jose Iram Mendonça do Rego, Antonio J. da Rocha. “Ears of the Lynx” Sign in a Marchiafava–Bignami patient: Structural Basis and Fiber‐Tracking DTI Contribution to the Understanding of this Imaging Abnormality. (2014) Journal of Neuroimaging. 24 (2): 205. doi:10.1111/j.1552-6569.2012.00714.x - Pubmed