Ears of the lynx sign (brain)

Last revised by Dalia Ibrahim ◉ on 21 Sep 2023

Citation, DOI, disclosures and article data

Citation:

Sarangi P, Ibrahim D, Bell D, et al. Ears of the lynx sign (brain). Reference article, Radiopaedia.org (Accessed on 03 Oct 2023) https://doi.org/10.53347/rID-65663

DOI:

https://doi.org/10.53347/rID-65663

Permalink:

https://radiopaedia.org/articles/65663

rID:

65663

Article created:

17 Jan 2019, Pradosh Kumar Sarangi

Disclosures:

At the time the article was created Pradosh Kumar Sarangi had no recorded disclosures.

View Pradosh Kumar Sarangi's current disclosures

Last revised:

21 Sep 2023, Dalia Ibrahim ◉

Disclosures:

At the time the article was last revised Dalia Ibrahim had no financial relationships to ineligible companies to disclose.

View Dalia Ibrahim's current disclosures

Revisions:

18 times, by 9 contributors - see full revision history and disclosures

Systems:

Central Nervous System

Sections:

Signs

Tags:

cases

Synonyms:

Ears of the lynx sign - brain

The ears of the lynx sign refers to abnormal T2/FLAIR cone-shaped hyperintensity at the tip of the frontal horn of the lateral ventricles in the region of forceps minor which resembles the tufts of hair crowning the ears of a lynx.

This sign is seen in hereditary spastic paraplegia with thin corpus callosum (HSP-TCC), the commonest form of which is spastic paraplegia 11 (SPG11), a form of hereditary spastic paraplegia associated with mutations of the identically-named spastic paraparesis gene 11 (SPG11) on chromosome 15 which codes for spatacsin ^1,2.

The sign may also be seen in:

SPG15, another cause of "hereditary spastic paraplegia with thin corpus callosum", which is caused by a mutation in the zinc finger five domain-containing protein 26 (ZFYVE26) gene, encoding spastizin
Marchiafava-Bignami disease ³