Lennox-Gastaut syndrome (LGS) is a form of refractory childhood-onset epilepsy and is often accompanied by developmental delay and psychological / behavioral problems.
An electroencephalogram (EEG) often shows a slow spike and wave pattern.
It is thought to often appear between the 2nd and 6th years of life, and is thereafter characterised by frequent seizures (up to 200 times an hour 4) and multiple seizure types.
History and etymology
It is named after William G. Lennox, a US neurologist (1884-1960) and Henri Gastaut a French neurologist (1915-1995) 4.
- 1. Ramanathan RS, Ahluwalia T, Sharma A. Lennox-Gastaut syndrome: An overview. J Pediatr Neurosci. 2010;5 (1): 86-8. doi:10.4103/1817-1745.66666 - Free text at pubmed - Pubmed citation
- 2. Correia JA, Schweder PM, Mews PJ et-al. Lennox-Gastaut Syndrome and idiopathic intracranial hypertension. J Clin Neurosci. 2010;17 (9): 1208-9. doi:10.1016/j.jocn.2010.01.025 - Pubmed citation
- 3. Gresham J, Eiland LS, Chung AM. Treating Lennox-Gastaut syndrome in epileptic pediatric patients with third-generation rufinamide. Neuropsychiatr Dis Treat. 2010;6 : 639-45. doi:10.2147/NDT.S6465 - Free text at pubmed - Pubmed citation
- 4. Lennox-Gastaut from whonamedit.com, the dictionary of medical eponyms. Lennox-Gastaut