Ossification of the posterior longitudinal ligament
Ossification of the posterior longitudinal ligament (OPLL) is typically an entity seen in patients of Asian descent, although it is seen in all ethnic groups. It is characterised by, as the name suggests, ossification of the posterior longitudinal ligament.
There is a recognised greater prevalence in males and in the elderly 3. There is also considerable racial variation:
- incidence in the Japanese/Asian population: 2.4%
- incidence in Caucasians: 0.2-0.7%
OPLL is twice as common in men compared with women. Symptoms usually manifest in the 4th-6th decades of life 7-8.
The exact pathogenesis of OPLL is rather unclear 3.
OPLL is often associated with several other entities:
- diffuse idiopathic skeletal hyperostosis (DISH)
- ossification of the ligamentum flavum (ossification of the yellow ligament (OYL))
- ankylosing spondylitis 3
- schizophrenia: possible (not confirmed)
DISH may be seen in up to 12% of elderly male Caucasians, with OPLL seen in about half of these, suggesting the incidence among Caucasians may be higher than the figures above.
This typically seen in the mid cervical spine and results central canal stenosis, predisposing the patient to cord injury from minor trauma:
- cervical: 75%
- thoracic: 15%
- lumbar: 10%
Stages of spinal cord damage by OPLL
- stage 0: normal or mild compression of anterior horn without neuronal loss
- stage 1: mild compression of anterior horn with partial neuronal loss.
- stage 2: marked deformity of anterior horn; severe neuronal loss.
- stage 3: severe spinal cord damage
T2-weighted sequences are considered the most effective in evaluation of spinal cord compression due to both the ossification and abnormal signal intensity of the spinal cord 5.
Treatment and prognosis
Management can range from being conservative to surgical removal. Surgical options can include anterior, posterior or combined approach. An anterior approaches (plated multilevel anterior discectomy and fusion, anterior cervical corpectomy with fusion (ACF)), may provide more direct decompression and best improve myelopathy. The soft-tissue morbidity associated with the anterior approach may be greater. Posterior approaches (e.g. laminectomy and fusion and laminoplasty) may be better tolerated in older patients 8.
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- 2. Koyanagi I, Iwasaki Y, Hida K et-al. Magnetic resonance imaging findings in ossification of the posterior longitudinal ligament of the cervical spine. J. Neurosurg. 1998;88 (2): 247-54. doi:10.3171/jns.1998.88.2.0247 - Pubmed citation
- 3. Saetia K, Cho D, Lee S et-al. Ossification of the posterior longitudinal ligament: a review. Neurosurg Focus. 2011;30 (3): E1. doi:10.3171/2010.11.FOCUS10276 - Pubmed citation
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- 7. Choi BW, Song KJ, Chang H. Ossification of the posterior longitudinal ligament: a review of literature. Asian Spine J. 2011;5 (4): 267-76. doi:10.4184/asj.2011.5.4.267 - Free text at pubmed - Pubmed citation
- 8. Smith ZA, Buchanan CC, Raphael D et-al. Ossification of the posterior longitudinal ligament: pathogenesis, management, and current surgical approaches. A review. Neurosurg Focus. 2011;30 (3): E10. doi:10.3171/2011.1.FOCUS10256 - Pubmed citation
- 9. Epstein N. Diagnosis and surgical management of cervical ossification of the posterior longitudinal ligament. Spine J. 2003;2 (6): 436-49. Pubmed citation