Papillary glioneuronal tumour

Dr Amir Rezaee et al.

Papillary glioneuronal tumours are a newly recognised entity on the 2007 WHO classification of CNS tumours. It is a rare well circumscribed complex solid cystic supratentorial lesion with indolent clinical course.


Papillary glioneural tumours are a WHO grade I with low proliferation index - MIB-1 index ~1-2%.

They contain both glial (astrocytic) and neural elements. Characteristic microscopic features are hyalinazied vascular pseudopapillary architecture with pseudostratified layer of cuboidal glial cells and focal collections of neurocytes and ganglion cells.

Radiographic features

Features on imaging are very similar to ganglioglioma. They are supratentorial solid-cystic or cystic with solid nodule lesions showing intense but heterogeneous enhancement. Calcification is a frequent finding.

  • T1: isointense to hypointense 
  • T2: inhomogeneously hyperintense
  • FLAIR:
    • inhomogeneously hyperintense nodule
    • cyst may suppress
  • Gd(C+): avid but heterogeneous enhancement of the nodule 
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Article Information

rID: 35516
Section: Pathology
Synonyms or Alternate Spellings:
  • Papillary glioneuronal tumours
  • Papillary glioneuronal tumor
  • Papillary glioneuronal tumors

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