Phthisis bulbi

Phthisis bulbi, also known as end-stage eye, is an atrophic scarred and disorganized globe that may result from a variety of severe ocular insults. 

In general, phthisis bulbi involves elderly patients, usually 65-85 years of age 7. Children and adolescents are only rarely affected, mainly due to ocular trauma and congenital malformations 7.

Typical clinical symptoms and signs include chronic ocular hypotension, a shrunken globe, pseudoenophthalmos, intraocular tissue fibrosis and scarring, visual loss, recurrent episodes of intraocular irritation and pain and swelling in and around the eye 7,8.

The globe is reduced in size (usually <20 mm) with a thickened/folded posterior sclera. Dystrophic calcification is common, and osseous metaplasia sometimes occurs, forming what is called "intraocular bone". 

Causes of this end-stage damage include:

  • small and shrunken globe with foci of calcium deposits and ossification in the sclera cornea, lens, retina, and optic nerve
  • distortion of globe components with challenging to separate and identify structures
  • fibrotic scarring with irregular globe contour and diffusely increased attenuation
  • small, shrunken, deformed, calcified globe with enophthalmos
  • abnormal intraocular contents deranged
  • T1: often with heterogeneous areas of increased signal, depending on the degree of calcification and hemorrhage
  • T2: mixed vitreous dark filling defects due to coarse calcifications
  • Flair: usually with increased signal

The globe is non-functioning, thus the patient is blind in that eye. Enucleation +/- prosthesis insertion is performed if there is associated chronic pain or for cosmetic reasons.

The differential includes other causes of calcification of the globe.

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Article information

rID: 1871
Section: Gamuts
Tag: orbit
Synonyms or Alternate Spellings:
  • End-stage eye

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Cases and figures

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  • Case 2: coronal
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  • Case 2: axial
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  • Case 3
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  • Case 4
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  • Case 5: on left
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  • Case 6
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  • Case 7: on plain film - left eye
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  • Case 8: bilateral
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  • Case 9
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