Systemic lupus erythematosus (gastrointestinal manifestations)

Last revised by Michael P Hartung on 26 Mar 2021

Gastrointestinal manifestations in patients with systemic lupus erythematosus are common and may involve any region of the gastrointestinal tract or visceral organs.

Patients with abdominal or gastrointestinal involvement by systemic lupus erythematosus may have a variety of presentations including abdominal pain, diarrhea, dysphagia, anorexia, ascites, oral ulcers, gastrointestinal bleeding and malnutrition depending on the organs involved and duration of involvement.

Systemic lupus erythematosus may affect any part of the gastrointestinal tract and visceral organs:

  • small bowel series: prominent mucosal pattern because of edema, segments of spiculation, fragmentation and clumping of barium 2
  • upper GI series: decreased esophageal peristalsis, reflux, esophageal dilatation

CT findings may include:

  • ascites with increased peritoneal enhancement
  • circumferential, symmetrical, multisegmented mural thickening usually of the jejunum and ileum with associated submucosal edema (target sign)
  • engorgement of mesenteric vessels with a palisade pattern or comb-like appearance
  • dilatation of intestinal segments
  • mesenteric fat stranding
  • diffuse splenic calcification in the typical "onion-skin" pattern due to concentric perivascular lamination of fibrous tissue
  • other features and complications of SLE disease may be present (e.g. pancreatitis, intestinal ischemia)

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Cases and figures

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  • Case 2
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