Thorotrast is a radioactive radiographic contrast agent containing thorium dioxide first produced in Germany in 1928 and was in use until the 1950s. It was used primarily for cerebral angiography, and 90% of the estimated 50,000-100,000 patients who received it were studied for this purpose.
The deposition of Thorotrast is dependant on its radiological use, preparation method, and the age of the preparation; however, the major site is the reticulo-endothelial system such as liver, spleen, bone marrow, lymph nodes. A plain film of the abdomen demonstrate fine, irregular metallic densities distributed throughout the liver, spleen and parapancreatic lymph nodes 4.
Thorotrast is carcinogenic with hepatic angiosarcomas being the classical thorotrast-related neoplasm. Other thorotrast-related neoplasms include:
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