Presentation
Recurrent patellar bone dislocation in osteogenesis imperfecta.
Patient Data
Age: 15 years
Gender: Female
From the case:
Zebra stripe sign
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Info
Numerous horizontal lines (zebra stripes) demonstrated at distal femur and proximal parts of tibia and fibula in a patient with history of osteogenesis imperfecta treated with bisphosphonate drugs.
Case Discussion
The zebra stripe sign occurs when children with osteogenesis imperfecta have been treated with cyclical bisphosphonate therapy, e.g. pamidronate disodium. When the drug is delivered in cycles, dense bone is formed while treatment is being given. This results in dense stripes across the metaphysis of bones which can be visualized radiographically as well as in MRI studies.
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