Anaplastic astrocytoma NOS

Case contributed by Juan José Gómez Muga
Diagnosis almost certain

Presentation

Subacute cognitive decline. Dizziness.

Patient Data

Age: 65 years
Gender: Male
ct
This study is a stack
Axial
non-contrast
This study is a stack
Axial C+
delayed
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Info

Hypodense left hemispheric lesion with mass effect. Midline shift, sulcal effacement and right lateral ventricle effacement. No enhancement with contrast.

mri
This study is a stack
Sagittal
T1
This study is a stack
Axial
T2
This study is a stack
Axial
FLAIR
This study is a stack
Axial
DWI
This study is a stack
Axial
ADC
This study is a stack
Coronal
T2
This study is a stack
Axial
T1
This study is a stack
Axial
T1 C+
This study is a stack
Axial MR
Perfusion (CBV)
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Info

Left temporoinsular lesion with mass effect. High signal on T2 and FLAIR sequences. No diffusion restriction. In the lateral margin there is a focal area of enhancement with increased rCBV on perfusion weighted images.

Case Discussion

Stereotactic biopsy was performed. Histology confirmed the diagnosis of anasplastic astrocytoma (WHO grade III).

Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumors, this tumor would, therefore, be designated as an anaplastic astrocytoma NOS.

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