Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Knipe H, Ashraf A, et al. Bethesda system for reporting thyroid cytopathology. Reference article, Radiopaedia.org (Accessed on 23 Mar 2025) https://doi.org/10.53347/rID-84429
Disclosures:
At the time the article was last revised Henry Knipe had the following disclosures:
- Micro-X Ltd, Shareholder (past)
These were assessed during peer review and were determined to
not be relevant to the changes that were made.
View Henry Knipe's current disclosures
The Bethesda system for reporting thyroid cytopathology comprises six categories of pathological reporting of thyroid FNA, with each category linked to a malignancy risk.
The Bethesda system was first published in 2010 and subsequently revised with the third edition published in 2023 to align with the 2022 WHO classification of thyroid tumors 3.
category I: non-diagnostic
category II: benign
category III: atypia of undetermined significance
category IV: suspicious for follicular neoplasm
category V: suspicious for malignancy
category VI: malignant
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1. Alshaikh S, Harb Z, Aljufairi E, Almahari S. Classification of Thyroid Fine-Needle Aspiration Cytology into Bethesda Categories: An Institutional Experience and Review of the Literature. Cytojournal. 2018;15:4. doi:10.4103/cytojournal.cytojournal_32_17 - Pubmed
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2. Kleiman D, Beninato T, Soni A, Shou Y, Zarnegar R, Fahey T. Does Bethesda Category Predict Aggressive Features in Malignant Thyroid Nodules? Ann Surg Oncol. 2013;20(11):3484-90. doi:10.1245/s10434-013-3076-5 - Pubmed
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3. VanderLaan P & Ali S. Brief Overview of the Updated Third Edition of the Bethesda System for Reporting Thyroid Cytopathology. Diagn Histopathol. 2023;29(11):499-502. doi:10.1016/j.mpdhp.2023.07.009
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