Dr Tim Luijkx and Radswiki et al.

Cellulitis (more specifically referred to as superficial cellulitis) is an acute infection of the dermis and subcutaneous tissues. It results in pain, erythema, oedema, and warmth. Since the epidermis is not involved, cellulitis is not transmitted by person-to-person contact.

Cellulitis occurs following disruption of the skin and invasion by microorganisms that may be indigenous flora, such as Staphylococcus aureus, or exogenous bacteria. Patients with peripheral vascular disease or diabetes are particularly susceptible to this type of infection, since minor injuries to the skin or cracked skin in the feet or toes can serve as a point of entry for infection.

Ultrasound is usually the first investigation to evaluate a clinical suspicion of cellulitis. Normally the subcutaneous tissue is hypoechoic with few hyperechoic strands (representing connective tissue).

  • In early cellulitis, there is a diffuse increase in the thickening and echogenicity of the subcutaneous tissue; helpful technique is to compare the tissue with contralateral side
  • later, there is accumulation of fluid in the subcutaneous tissue, giving it a "cobble-stone appearance" (this appearance is not specific for cellulitis, but is seen in subcutaneous edema due to any cause)

CT is used to accurately differentiate between superficial cellulitis and deep cellulitis (cellulitis associated with deep-seated infection). 

In uncomplicated cellulitis, CT demonstrates skin thickening, septation of the subcutaneous fat, and thickening of the underlying superficial fascia. If the infection spreads to deeper tissues, deep cellulitis, soft-tissue abscess, infectious myositis, necrotising fasciitis, and osteomyelitis can all be detected with CT.

Uncomplicated cellulitis is a clinical diagnosis and is treated conservatively with antibiotics and locally supportive measures. If the infection spreads to deeper tissues complications and associated pathology can occur, e.g. deep cellulitissoft-tissue abscessinfectious myositisnecrotising fasciitis, or osteomyelitis. Special consideration should be given to geriatric patients, in whom cellulitis of the lower extremities is more likely to develop into thrombophlebitis.

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Article information

rID: 15554
Synonyms or Alternate Spellings:
  • Superficial cellulitis

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Cases and figures

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    Figure 1: clinical photograph
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    Figure 2: proximal forearm
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    Case 1: orbital and periorbital cellulitis
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    Case 2: leg
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    Diffuse subcutane...
    Case 3: upper limb
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    Case 4: cobblestone appearance
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