Cystic glioblastoma

Cystic glioblastoma is a descriptive term to one form of glioblastoma that contains large cystic component, rather than being a pathological subtype. 

Please refer to the main article on glioblastoma for a broad discussion on this tumour. 

Radiographic features

The main challenge in discrimination between intracranial cystic lesions is to differentiate benign inflammatory cystic lesions (as cerebral abscess) from malignant cystic lesions (as cystic metastasis and cystic glioma) which have totally different management.

CT
  • well defined intra-axial cystic lesion with peripheral ring enhancement
  • usually presents with mass effect.
  • mild perifocal oedema.
  • enhancing margin as well as the soft tissue component.
MRI
  • T1: homogeneously hypointense
  • T1 C+ (Gd) solid component usually enhances
  • T2: hyperintense
  • FLAIR: cystic areas show hyperintensity relative to CSF due to higher protein contents
  • DWI: no restriction for the cystic component; the solid component may show restriction according to the grade
  • MR spectroscopy: high Cho/Cr ratio
  • MR perfusion: no appreciable perfusion changes could be usually seen

Differential diagnosis

mMaging differential considerations include

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Article information

rID: 42435
Section: Pathology
Tags: refs, cases
Synonyms or Alternate Spellings:
  • C-GBM
  • Cystic GBM
  • Cystic glioblastoma multiforme
  • Cystic glioblastomas

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