Glioblastoma NOS
Citation, DOI, disclosures and article data
At the time the article was created Frank Gaillard had no recorded disclosures.
View Frank Gaillard's current disclosuresAt the time the article was last revised Arlene Campos had no financial relationships to ineligible companies to disclose.
View Arlene Campos's current disclosuresGlioblastoma NOS (not otherwise specified) is a diagnosis in the 2021 WHO classification of CNS tumors and denotes a diffuse glioma with astrocytic features and anaplasia, microvascular proliferation and/or necrosis consistent with a WHO grade 4 tumor but with inconclusive or unavailable IDH mutation status 1,2.
As such, much of the older literature on glioblastomas should be considered to describe glioblastoma NOS.
As most glioblastoma NOS are in actuality glioblastoma IDH wild-type (just with unavailable IDH status), they are discussed as part of the main glioblastoma article.
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References
- 1. Louis D, Ohgaki H, Wiestler O et al. The 2007 WHO Classification of Tumours of the Central Nervous System. Acta Neuropathol. 2007;114(2):97-109. doi:10.1007/s00401-007-0243-4 - Pubmed
- 2. Louis D, Perry A, Wesseling P et al. The 2021 WHO Classification of Tumors of the Central Nervous System: A Summary. Neuro-Oncology. 2021;23(8):1231-51. doi:10.1093/neuonc/noab106 - Pubmed
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astrocytic tumors
- WHO classification of CNS tumors
- WHO grading of CNS tumors
- VASARI MRI feature set
- diffuse astrocytoma grading
- grade I:
- grade II:
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low-grade diffuse astrocytoma
- fibrillary astrocytoma (no longer recognized)
- protoplasmic astrocytoma (no longer recognized)
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- oligoastrocytoma (no longer recognized)
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- grade IV:
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glioblastoma (GBM)
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glioblastoma (GBM)
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