Good syndrome

Last revised by Daniel J Bell on 9 Jun 2020

Citation, DOI, disclosures and article data

Citation:

Morgan M, Bell D, Weerakkody Y, et al. Good syndrome. Reference article, Radiopaedia.org (Accessed on 19 Apr 2024) https://doi.org/10.53347/rID-37012

DOI:

https://doi.org/10.53347/rID-37012

Permalink:

https://radiopaedia.org/articles/37012

rID:

37012

Article created:

22 May 2015, Matt A. Morgan ◉

Disclosures:

At the time the article was created Matt A. Morgan had no recorded disclosures.

View Matt A. Morgan's current disclosures

Last revised:

9 Jun 2020, Daniel J Bell ◉

Disclosures:

At the time the article was last revised Daniel J Bell had no recorded disclosures.

View Daniel J Bell's current disclosures

Revisions:

4 times, by 4 contributors - see full revision history and disclosures

Systems:

Chest

Sections:

Syndromes

Tags:

thymoma, paraneoplastic, stub

Synonyms:

Good's syndrome

Good syndrome is a rare paraneoplastic syndrome in which a thymoma causes hypogammaglobulinemia and humoral immunodeficiency. It has been estimated to occur in 0.2%–2% of thymomas ².

thymoma
low to absent B-cells
T-cell mediated defects
- CD4 T-cell lymphopenia
- inverted CD4/CD8+ T-cell ratio

Patients with Good syndrome are highly susceptible to bacterial infections. Radiologically, patients with a thymoma may present with findings compatible with immunodeficiency, such as chronic lung disease.