- low to absent B-cells
- T-cell mediated defects
- CD4 T-cell lymphopenia
- inverted CD4/CD8+ T-cell ratio
Patients with Good syndrome are highly susceptible to bacterial infections. Radiologically, patients with a thymoma may present with findings compatible with immunodeficiency, such as chronic lung disease.
- 1. Malphettes M, Gérard L, Galicier L et-al. Good Syndrome: An Adult-Onset Immunodeficiency Remarkable for Its High Incidence of Invasive Infections and Autoimmune Complications. Clin. Infect. Dis. . doi:10.1093/cid/civ269 - Pubmed citation
- 2. Kelleher P, Misbah SA. What is Good's syndrome? Immunological abnormalities in patients with thymoma. J. Clin. Pathol. 2003;56 (1): 12-6. Free text at pubmed - Pubmed citation
- 3. Kelly A, Merlin C, Trouillier S et-al. Thymoma and immunodeficiency: (18)F-FDG-PET/CT imaging of Good syndrome. Hell J Nucl Med. 2013;16 (2): 140-1. Pubmed citation
- 4. Good, R. A. "Agammaglobulinemia: a provocative experiment of nature." Bull Univ Minn 26 (1954): 1-19.