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Good syndrome

Good syndrome is a rare paraneoplastic syndrome in which a thymoma causes hypogammaglobulinemia and humoral immunodeficiency. It has been estimated to occur in 0.2%–2% of thymomas 2.

  • thymoma
  • low to absent B-cells
  • T-cell mediated defects
    • CD4 T-cell lymphopenia
    • inverted CD4/CD8+ T-cell ratio

Patients with Good syndrome are highly susceptible to bacterial infections. Radiologically, patients with a thymoma may present with findings compatible with immunodeficiency, such as chronic lung disease. 

History and etymology

Good syndrome was first described by Robert "Bob" Alan Good, (1922-2003) 7 an American immunologist, in 1955 4-6.

Article information

rID: 37012
System: Chest
Section: Syndromes
Synonyms or Alternate Spellings:
  • Good's syndrome

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