Hemangiopericytoma

Hemangiopericytoma is a term formerly used to describe a continuum of mesenchymal tumors with elevated cellularity found throughout the body in soft tissue and bone. After many years of controversy, hemangiopericytomas have been shown to not only share histological features similar to solitary fibrous tumors but also similar genetic alteration: genomic inversion of 12q13 locus resulting in fusion of NAB2 and STAT6 genes, the latter expressed and able to be assessed using immunohistochemistry techniques 4.

As a result, systemically the term "hemangiopericytoma" is no longer routinely used. In the central nervous system, because the appearances of hemangiopericytomas and solitary fibrous tumors are quite different, the distinction has been somewhat kept; in the most recent WHO classification of CNS tumors (2016 update to 4th edition) meningeal hemangiopericytoma and solitary fibrous tumor of the dura are considered as one entity 4

History and etymology

The term was first used by the American pathologists Arthur Purdy Stout and Margaret Ransone Murray in 1942 to describe a soft tissue tumor presumably of pericytic origin, with a monomorphic population of compact polygonal or fusiform cells and a branching stromal vascular pattern with a "staghorn" form 3,4

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Article information

rID: 1436
System: Vascular
Tag: cases
Synonyms or Alternate Spellings:
  • Hemangiopericytoma
  • Haemagiopericytomas
  • Hemagiopericytoma
  • Hemagiopericytomas
  • Hemangioperictyoma - general
  • Haemangioperictyoma - general
  • Cellular solitary fibrous tumor
  • Cellular SFT
  • Solitary fibrous tumor, hemangiopericytoma type

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Cases and figures

  • Pulmonary angiogr...
    Case 1: pleural solitary fibrous tumor
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  • Case 2: meningeal hemangiopericytoma
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